Drug Interactions

Buprenorphine metabolizes to norbuprenorphine via cytochrome CYP 3A4. Therefore, you should consider lower doses of buprenorphine for patients who are already taking cytochrome inhibitors (eg: azole antifungals, macrolide antibiotics, HIV antivirals, and protease inhibitors). Failure to do so may cause an increase in the plasma concentration of buprenorphine. Central nervous system depressants taken at the same time as buprenorphine might cause serious overdose or death. These include:

  • Benzodiazepines
  • Alcohol
  • Sedatives
  • Tranquilizers
  • Antidepressants
Related Resources: 
Description: 
List of drugs that interact with buprenorphine due to their metabolism by Cytochrome P450.
Source: 
Indiana University School of Medicine
field_vote: 
Description: 
Guideline document discussing interactions between buprenorphine and HIV medication.
Source: 
Physician Clinical Support System (PCSS)
field_vote: 
Description: 
Find the links to each buprenorphine formulation's medication guide here
Source: 
FDA
field_vote: 
Patient Handouts: